WebCompounds belonging to class B are inactive as either the monoacetylated (3-acetyl-2α-hydroxy-22-epi-hippuristanol) or the diacetylated (3,2-diacetyl-22-epi-hippuristanol) derivatives. On the other hand, for compounds in class C, the oxidation level at C-3, that is, the hydroxyl group ( 169 ) or ketone ( 170 ), does not influence the activity. WebTable of contents : Front Matter....Pages 0-0 Introduction to Marine Biotechnology....Pages 1-10 Front Matter....Pages 11-11 Marine Fungal Diversity and Bioprospecting....Pages 13-25 Diversity of Marine Phototorophs....Pages 27-34 Marine Viruses....Pages 35-49 Marine Microalgae....Pages 51-63 Seaweed Flora of the European North Atlantic and …
A comparative study of small molecules targeting eIF4A
WebMay 15, 2010 · Hippuristanol is a natural product that has recently been shown to inhibit eukaryotic translation initiation and tumor cell proliferation. To investigate the structure … WebMar 15, 2011 · To investigate the mechanisms by which hippuristanol reduced the cell viability of HTLV-1-infected T-cell lines, we analyzed the frequency of apoptotic cells by … golden chick arlington texas
Multiple components of eIF4F are required for protein synthesis ...
WebJan 4, 2016 · Hippuristanol is a member of one of 4 classes of polyoxygenated steroids. These include (i) the hippurin or hippuristanol type containing a spiroketal ring, (ii) the gorgosterol type containing a cyclopropane residue; (iii) the hippuristerone type possessing a 3-keto functionality, and (iv) the hippuristerol type (Fig. 2A). WebMoreover, given that the Sal treatments rendered unpromising results, we explored alternatives to sensitize cancer cells. Several small molecules known to disrupt eIF4A RNA helicase have been reported to possess anticancer activity both in vitro and in vivo, including rocaglates, hippuristanol, rohinitib, and pateamine A (PatA) [82,83]. WebMay 24, 2024 · Here, we show the application of carbene footprinting to the interaction between eIF4A helicase and a natural product inhibitor, hippuristanol, found in the coral Isis hippuris. Upon addition of hippuristanol we identified reduced carbene labelling (masking) in regions of eIF4A previously implicated in ligand binding. hcw realty