WebSep 24, 2024 · Circular RNAs (circRNAs) generally bind to RNA-binding proteins (RBPs) to play an important role in the regulation of autoimmune diseases. ... Xiaoyong Pan, … WebAbstract. The widespread expression of circular RNAs (circRNAs) is regarded as a feature of gene expression in highly diverged eukaryotes. Recent studies have shown that …
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WebJun 22, 2024 · SCD-circRNA 2 is an independent risk factor for predicting prognosis of HCC patients. We also found that the biogenesis of SCD-circRNA 2 was promoted by RNA-binding protein 3 (RBM3). Strikingly, RBM3 expression is increased dramatically in HCC tissues, and the RBM3 level correlates positively with poor survival. WebJun 1, 2024 · Accumulating evidence indicates that circRNAs play significant roles in physiological and pathological processes by acting as microRNA (miRNA) and RNA-binding protein (RBP) sponges, regulators of transcription and splicing [3], and translators to produce polypeptides.
WebSep 24, 2024 · Circular RNAs (circRNAs) are a new type of long noncoding RNAs, and they are found in thousands of lives including plants, animals and humans [ 1 ]. Unlike linear RNAs, circRNAs have a circular closed loop structure, which do not contain 5′ caps and 3′ poly (A) structure. In addition, circRNAs’ expression is more stable. Webdata sets of protein-circRNA binding sites, CRIP achieves higher prediction accuracy compared with both the traditional classi ers and state-of-the-art deep learning models. As far as we know, this is the rst predictor for circRNA-protein interactions using machine learning, which will assist in revealing important roles of circRNAs in gene ...
WebMar 31, 2024 · Luciferase reporter assay and RNA Binding Protein Immunoprecipitation (RIP) were used to demonstrate the underlying mechanism of circRNA_17725. ... Additionally, circRNA_17725-overexpressed macrophages alleviated arthritis and protected against joint injuries and bone destruction by inducing macrophage polarization towards … WebJan 22, 2024 · The circRNA-binding-proteins (circRBPs) include transcription factors, RNA processing proteins, proteases, and common RNA-binding-proteins (RBPs) that can …
WebAug 7, 2024 · Prediction analysis and mechanistic identification revealed that cIARS physically interacted with RNA binding protein (RBP) ALKBH5, which was a negative regulator of autophagic flux in HCC.
WebMar 12, 2015 · To identify splicing-associated factors involved in circRNA biogenesis, we first selected a candidate panel of nuclear RNA binding proteins (RBPs) (based on Gene Ontology annotations) that were expressed at appreciable levels (>0.1 FPKM in polyA + RNA-sequencing from at least one sample) and were changed in abundance by >2-fold, … how to make lincolnshire sausagesWebFeb 26, 2024 · The physiological and pathological functions of circRNAs occur through miRNA sponging, interacting with circRNA binding proteins (cRBPs), protein translation, or transcriptional regulation. CircRNAs play roles in regulation of cancer development, cardiovascular diseases, neurogenesis and neurological disorders, and metabolic diseases. how to make linear interpolation in excelWeb]. circRNA biogenesis can be mediated by RNA-binding proteins (RBPs) [ 16. ], intronic complementary sequences (ICSs) [ 17. ], or a lariat-driven back-splicing mechanism [ 18. ]. Currently, the profiles, functions, and mechanisms of how circRNAs exert effects on physiological and pathological states are emerging and remain under discussion. mst and pst timeWebJan 7, 2024 · Increasingly, studies have revealed that some circRNAs may “sponge” RBPs (RNA-binding proteins) [ 12, 13, 14, 15 ], thereby modulating protein–protein … how to make lineart betterWebNov 28, 2024 · CiRS-7 was the first circRNA to be validated as a miRNA sponge and was verified to contain more than 70 selectively conserved binding sites for miR-7 . Hsa_circRNA_101237 was found to be an important onco-circRNA of non-small cell lung cancer (NSCLC) that sponges miRNA-490-3p and thus promotes the expression of … mst and ptsdWebAug 4, 2024 · CircRNAs regulate gene expression by interacting with cellular regulators such as microRNAs and RNA binding proteins (RBPs) to regulate downstream gene expression. The accumulation of high-throughput RNA–protein interaction data revealed the interaction of RBPs with the coding and noncoding RNAs, including recently discovered … ms. tan is the real boss readwnWebFeb 28, 2024 · Finally, we validated that CPSF6, as a circRNA-binding protein, interacted with and regulated its circular isoform circCPSF6 (hsa_circ_0000417), of which depletion also resulted in cell cycle ... how to make linear regression model