WebOct 1, 2024 · Small-molecule AgrA inhibitors F12 and F19 act as antivirulence agents against Gram-positive pathogens Scientific Reports Your Privacy nature scientific reports articles article Article Open... WebOct 17, 2024 · The molecules cling to a toxin-making protein found across Gram-positive bacterial species, called AgrA, rendering it ineffective. Treating mice with the therapeutic molecules effectively cured...
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WebSep 16, 2010 · AgrA, however, needs to be activated to induce toxin production. His goal was to block the activation of AgrA with a drug, thus preventing the cascade of toxin release into the blood that can... WebApr 6, 2024 · Other examples of antivirulence agents include the small molecule inhibitors of AgrA (Accessory gene regulator A; Gomes-Fernandes et al. 2024) a protein which is a regulator of gene transcription and the production of secreted virulence factor.Such small molecule inhibitors include the substituted resorcinol-based ketones F12 and F19 (Fig. … buy one get free chipotle
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WebIn this paper molecular docking study was done for savirin and its thirty derivatives with AgrA protein (PDB ID: 4G4K) of S. aureus in order to find out potential inhibitors of … WebOct 1, 2024 · Here we show that the small-molecule antivirulence agents F12 and F19 block staphylococcal transcription factor AgrA from binding to its promoter. Consequently, toxin expression is inhibited, thus preventing host cell damage by Gram-positive pathogens. WebFeb 23, 2015 · Agr inhibitors with clearly defined mechanisms of action include the monoclonal antibody (mAb) against AIP of group IV, AIP analogues that inhibit AgrC activation, and the AgrA inhibitor savarin. buy one get half off